GlutaredoxinV1, Main, Exploration, bibRecord, 000238

PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways.

Identifieur interne : 000238 ( Main/Exploration ); précédent : 000237; suivant : 000239

PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways.

Auteurs : Eun Ji Ryu ; Dae Won Kim ; Min Jea Shin ; Hyo Sang Jo ; Jung Hwan Park ; Su Bin Cho ; Chi Hern Lee ; Hyeon Ji Yeo ; Eun Ji Yeo ; Yeon Joo Choi ; Duk-Soo Kim ; Sung-Woo Cho ; Yong-Jun Cho ; Eun Jeong Sohn ; Ora Son ; Keun Wook Lee ; Kyu Hyung Han ; Jinseu Park ; Won Sik Eum ; Soo Young Choi

Source :

Molecular medicine reports [ 1791-3004 ] ; 2018.

RBID : pubmed:29916538

Descripteurs français

KwdFr :
- Animaux (MeSH), Encéphalopathie ischémique (anatomopathologie), Encéphalopathie ischémique (métabolisme), Encéphalopathie ischémique (traitement médicamenteux), Glutarédoxines (pharmacologie), Hippocampe (anatomopathologie), Hippocampe (métabolisme), Lignée cellulaire (MeSH), Mercaptamine (analogues et dérivés), Mercaptamine (pharmacologie), Neurones (anatomopathologie), Neurones (métabolisme), Peptides (pharmacologie), Souris (MeSH), Stress oxydatif (effets des médicaments et des substances chimiques), Système de signalisation des MAP kinases (effets des médicaments et des substances chimiques).
MESH :
- analogues et dérivés : Mercaptamine.
- anatomopathologie : Encéphalopathie ischémique, Hippocampe, Neurones.
- effets des médicaments et des substances chimiques : Stress oxydatif, Système de signalisation des MAP kinases.
- métabolisme : Encéphalopathie ischémique, Hippocampe, Neurones.
- pharmacologie : Glutarédoxines, Mercaptamine, Peptides.
- traitement médicamenteux : Encéphalopathie ischémique.
- Animaux, Lignée cellulaire, Souris.

English descriptors

KwdEn :
- Animals (MeSH), Brain Ischemia (drug therapy), Brain Ischemia (metabolism), Brain Ischemia (pathology), Cell Line (MeSH), Cysteamine (analogs & derivatives), Cysteamine (pharmacology), Glutaredoxins (pharmacology), Hippocampus (metabolism), Hippocampus (pathology), MAP Kinase Signaling System (drug effects), Mice (MeSH), Neurons (metabolism), Neurons (pathology), Oxidative Stress (drug effects), Peptides (pharmacology).
MESH :
- chemical , analogs & derivatives : Cysteamine.
- drug effects : MAP Kinase Signaling System, Oxidative Stress.
- drug therapy : Brain Ischemia.
- metabolism : Brain Ischemia, Hippocampus, Neurons.
- pathology : Brain Ischemia, Hippocampus, Neurons.
- chemical , pharmacology : Cysteamine, Glutaredoxins, Peptides.
- Animals, Cell Line, Mice.

Abstract

Oxidative stress is known to be a primary risk factor for neuronal diseases. Glutaredoxin (GLRX)‑1, a redox‑regulator of the thioredoxin superfamily, is known to exhibit an important role in cell survival via various cellular functions. However, the precise roles of GLRX1 in brain ischemia are still not fully understood. The present study investigated whether transduced PEP‑1‑GLRX1 protein has protective effects against oxidative stress in cells and in an animal model. Transduced PEP‑1‑GLRX1 protein increased HT‑22 cell viability under oxidative stress and this fusion protein significantly reduced intracellular reactive oxygen species and levels of DNA damage. In addition, PEP‑1‑GLRX1 protein regulated RAC‑a serine/threonine‑protein kinase and mitogen‑activated protein kinase signaling, in addition to apoptotic signaling including B cell lymphoma (Bcl)‑2, Bcl‑2 associated X, apoptosis regulator, pro‑caspase‑9 and p53 expression levels. In an ischemic animal model, it was verified that PEP‑1‑GLRX1 transduced into the Cornu Ammonis 1 region of the animal brain, where it markedly protected against ischemic injury. These results indicate that PEP‑1‑GLRX1 attenuates neuronal cell death resulting from oxidative stress in vitro and in vivo. Therefore, PEP‑1‑GLRX1 may exhibit a beneficial role in the treatment of neuronal disorders, including ischemic injury.

DOI: 10.3892/mmr.2018.9176
PubMed: 29916538

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000233
to stream Main, to step Curation: 000233

Le document en format XML

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<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
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<author><name sortKey="Kim, Dae Won" sort="Kim, Dae Won" uniqKey="Kim D" first="Dae Won" last="Kim">Dae Won Kim</name>
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<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
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<author><name sortKey="Shin, Min Jea" sort="Shin, Min Jea" uniqKey="Shin M" first="Min Jea" last="Shin">Min Jea Shin</name>
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<author><name sortKey="Park, Jung Hwan" sort="Park, Jung Hwan" uniqKey="Park J" first="Jung Hwan" last="Park">Jung Hwan Park</name>
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<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
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<author><name sortKey="Cho, Su Bin" sort="Cho, Su Bin" uniqKey="Cho S" first="Su Bin" last="Cho">Su Bin Cho</name>
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<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
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<author><name sortKey="Lee, Chi Hern" sort="Lee, Chi Hern" uniqKey="Lee C" first="Chi Hern" last="Lee">Chi Hern Lee</name>
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<author><name sortKey="Yeo, Hyeon Ji" sort="Yeo, Hyeon Ji" uniqKey="Yeo H" first="Hyeon Ji" last="Yeo">Hyeon Ji Yeo</name>
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<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
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<author><name sortKey="Yeo, Eun Ji" sort="Yeo, Eun Ji" uniqKey="Yeo E" first="Eun Ji" last="Yeo">Eun Ji Yeo</name>
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<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
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<author><name sortKey="Choi, Yeon Joo" sort="Choi, Yeon Joo" uniqKey="Choi Y" first="Yeon Joo" last="Choi">Yeon Joo Choi</name>
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<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
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<author><name sortKey="Kim, Duk Soo" sort="Kim, Duk Soo" uniqKey="Kim D" first="Duk-Soo" last="Kim">Duk-Soo Kim</name>
<affiliation><nlm:affiliation>Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan‑Si, South Chungcheong 31538, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cho, Sung Woo" sort="Cho, Sung Woo" uniqKey="Cho S" first="Sung-Woo" last="Cho">Sung-Woo Cho</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cho, Yong Jun" sort="Cho, Yong Jun" uniqKey="Cho Y" first="Yong-Jun" last="Cho">Yong-Jun Cho</name>
<affiliation><nlm:affiliation>Department of Neurosurgery, Hallym University Medical Center, Chuncheon, Gangwon 24253, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sohn, Eun Jeong" sort="Sohn, Eun Jeong" uniqKey="Sohn E" first="Eun Jeong" last="Sohn">Eun Jeong Sohn</name>
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<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Son, Ora" sort="Son, Ora" uniqKey="Son O" first="Ora" last="Son">Ora Son</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lee, Keun Wook" sort="Lee, Keun Wook" uniqKey="Lee K" first="Keun Wook" last="Lee">Keun Wook Lee</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Han, Kyu Hyung" sort="Han, Kyu Hyung" uniqKey="Han K" first="Kyu Hyung" last="Han">Kyu Hyung Han</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Park, Jinseu" sort="Park, Jinseu" uniqKey="Park J" first="Jinseu" last="Park">Jinseu Park</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Eum, Won Sik" sort="Eum, Won Sik" uniqKey="Eum W" first="Won Sik" last="Eum">Won Sik Eum</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Choi, Soo Young" sort="Choi, Soo Young" uniqKey="Choi S" first="Soo Young" last="Choi">Soo Young Choi</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways.</title>
<author><name sortKey="Ryu, Eun Ji" sort="Ryu, Eun Ji" uniqKey="Ryu E" first="Eun Ji" last="Ryu">Eun Ji Ryu</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kim, Dae Won" sort="Kim, Dae Won" uniqKey="Kim D" first="Dae Won" last="Kim">Dae Won Kim</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung‑Wonju National University, Gangneung, Gangwon 25457, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shin, Min Jea" sort="Shin, Min Jea" uniqKey="Shin M" first="Min Jea" last="Shin">Min Jea Shin</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Jo, Hyo Sang" sort="Jo, Hyo Sang" uniqKey="Jo H" first="Hyo Sang" last="Jo">Hyo Sang Jo</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Park, Jung Hwan" sort="Park, Jung Hwan" uniqKey="Park J" first="Jung Hwan" last="Park">Jung Hwan Park</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cho, Su Bin" sort="Cho, Su Bin" uniqKey="Cho S" first="Su Bin" last="Cho">Su Bin Cho</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lee, Chi Hern" sort="Lee, Chi Hern" uniqKey="Lee C" first="Chi Hern" last="Lee">Chi Hern Lee</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yeo, Hyeon Ji" sort="Yeo, Hyeon Ji" uniqKey="Yeo H" first="Hyeon Ji" last="Yeo">Hyeon Ji Yeo</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yeo, Eun Ji" sort="Yeo, Eun Ji" uniqKey="Yeo E" first="Eun Ji" last="Yeo">Eun Ji Yeo</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Choi, Yeon Joo" sort="Choi, Yeon Joo" uniqKey="Choi Y" first="Yeon Joo" last="Choi">Yeon Joo Choi</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kim, Duk Soo" sort="Kim, Duk Soo" uniqKey="Kim D" first="Duk-Soo" last="Kim">Duk-Soo Kim</name>
<affiliation><nlm:affiliation>Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan‑Si, South Chungcheong 31538, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cho, Sung Woo" sort="Cho, Sung Woo" uniqKey="Cho S" first="Sung-Woo" last="Cho">Sung-Woo Cho</name>
<affiliation><nlm:affiliation>Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Cho, Yong Jun" sort="Cho, Yong Jun" uniqKey="Cho Y" first="Yong-Jun" last="Cho">Yong-Jun Cho</name>
<affiliation><nlm:affiliation>Department of Neurosurgery, Hallym University Medical Center, Chuncheon, Gangwon 24253, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sohn, Eun Jeong" sort="Sohn, Eun Jeong" uniqKey="Sohn E" first="Eun Jeong" last="Sohn">Eun Jeong Sohn</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Son, Ora" sort="Son, Ora" uniqKey="Son O" first="Ora" last="Son">Ora Son</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lee, Keun Wook" sort="Lee, Keun Wook" uniqKey="Lee K" first="Keun Wook" last="Lee">Keun Wook Lee</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Han, Kyu Hyung" sort="Han, Kyu Hyung" uniqKey="Han K" first="Kyu Hyung" last="Han">Kyu Hyung Han</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Park, Jinseu" sort="Park, Jinseu" uniqKey="Park J" first="Jinseu" last="Park">Jinseu Park</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Eum, Won Sik" sort="Eum, Won Sik" uniqKey="Eum W" first="Won Sik" last="Eum">Won Sik Eum</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Choi, Soo Young" sort="Choi, Soo Young" uniqKey="Choi S" first="Soo Young" last="Choi">Soo Young Choi</name>
<affiliation><nlm:affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</nlm:affiliation>
<wicri:noCountry code="subField">Republic of South Korea</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecular medicine reports</title>
<idno type="eISSN">1791-3004</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Brain Ischemia (drug therapy)</term>
<term>Brain Ischemia (metabolism)</term>
<term>Brain Ischemia (pathology)</term>
<term>Cell Line (MeSH)</term>
<term>Cysteamine (analogs & derivatives)</term>
<term>Cysteamine (pharmacology)</term>
<term>Glutaredoxins (pharmacology)</term>
<term>Hippocampus (metabolism)</term>
<term>Hippocampus (pathology)</term>
<term>MAP Kinase Signaling System (drug effects)</term>
<term>Mice (MeSH)</term>
<term>Neurons (metabolism)</term>
<term>Neurons (pathology)</term>
<term>Oxidative Stress (drug effects)</term>
<term>Peptides (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Encéphalopathie ischémique (anatomopathologie)</term>
<term>Encéphalopathie ischémique (métabolisme)</term>
<term>Encéphalopathie ischémique (traitement médicamenteux)</term>
<term>Glutarédoxines (pharmacologie)</term>
<term>Hippocampe (anatomopathologie)</term>
<term>Hippocampe (métabolisme)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Mercaptamine (analogues et dérivés)</term>
<term>Mercaptamine (pharmacologie)</term>
<term>Neurones (anatomopathologie)</term>
<term>Neurones (métabolisme)</term>
<term>Peptides (pharmacologie)</term>
<term>Souris (MeSH)</term>
<term>Stress oxydatif (effets des médicaments et des substances chimiques)</term>
<term>Système de signalisation des MAP kinases (effets des médicaments et des substances chimiques)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Cysteamine</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Mercaptamine</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphalopathie ischémique</term>
<term>Hippocampe</term>
<term>Neurones</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>MAP Kinase Signaling System</term>
<term>Oxidative Stress</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Brain Ischemia</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Stress oxydatif</term>
<term>Système de signalisation des MAP kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Ischemia</term>
<term>Hippocampus</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Encéphalopathie ischémique</term>
<term>Hippocampe</term>
<term>Neurones</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Ischemia</term>
<term>Hippocampus</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Glutarédoxines</term>
<term>Mercaptamine</term>
<term>Peptides</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cysteamine</term>
<term>Glutaredoxins</term>
<term>Peptides</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Encéphalopathie ischémique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Lignée cellulaire</term>
<term>Souris</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Oxidative stress is known to be a primary risk factor for neuronal diseases. Glutaredoxin (GLRX)‑1, a redox‑regulator of the thioredoxin superfamily, is known to exhibit an important role in cell survival via various cellular functions. However, the precise roles of GLRX1 in brain ischemia are still not fully understood. The present study investigated whether transduced PEP‑1‑GLRX1 protein has protective effects against oxidative stress in cells and in an animal model. Transduced PEP‑1‑GLRX1 protein increased HT‑22 cell viability under oxidative stress and this fusion protein significantly reduced intracellular reactive oxygen species and levels of DNA damage. In addition, PEP‑1‑GLRX1 protein regulated RAC‑a serine/threonine‑protein kinase and mitogen‑activated protein kinase signaling, in addition to apoptotic signaling including B cell lymphoma (Bcl)‑2, Bcl‑2 associated X, apoptosis regulator, pro‑caspase‑9 and p53 expression levels. In an ischemic animal model, it was verified that PEP‑1‑GLRX1 transduced into the Cornu Ammonis 1 region of the animal brain, where it markedly protected against ischemic injury. These results indicate that PEP‑1‑GLRX1 attenuates neuronal cell death resulting from oxidative stress in vitro and in vivo. Therefore, PEP‑1‑GLRX1 may exhibit a beneficial role in the treatment of neuronal disorders, including ischemic injury.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29916538</PMID>
<DateCompleted><Year>2018</Year>
<Month>10</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>10</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1791-3004</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>18</Volume>
<Issue>2</Issue>
<PubDate><Year>2018</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Molecular medicine reports</Title>
<ISOAbbreviation>Mol Med Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways.</ArticleTitle>
<Pagination><MedlinePgn>2216-2228</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3892/mmr.2018.9176</ELocationID>
<Abstract><AbstractText>Oxidative stress is known to be a primary risk factor for neuronal diseases. Glutaredoxin (GLRX)‑1, a redox‑regulator of the thioredoxin superfamily, is known to exhibit an important role in cell survival via various cellular functions. However, the precise roles of GLRX1 in brain ischemia are still not fully understood. The present study investigated whether transduced PEP‑1‑GLRX1 protein has protective effects against oxidative stress in cells and in an animal model. Transduced PEP‑1‑GLRX1 protein increased HT‑22 cell viability under oxidative stress and this fusion protein significantly reduced intracellular reactive oxygen species and levels of DNA damage. In addition, PEP‑1‑GLRX1 protein regulated RAC‑a serine/threonine‑protein kinase and mitogen‑activated protein kinase signaling, in addition to apoptotic signaling including B cell lymphoma (Bcl)‑2, Bcl‑2 associated X, apoptosis regulator, pro‑caspase‑9 and p53 expression levels. In an ischemic animal model, it was verified that PEP‑1‑GLRX1 transduced into the Cornu Ammonis 1 region of the animal brain, where it markedly protected against ischemic injury. These results indicate that PEP‑1‑GLRX1 attenuates neuronal cell death resulting from oxidative stress in vitro and in vivo. Therefore, PEP‑1‑GLRX1 may exhibit a beneficial role in the treatment of neuronal disorders, including ischemic injury.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ryu</LastName>
<ForeName>Eun Ji</ForeName>
<Initials>EJ</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Dae Won</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, Research Institute of Oral Sciences, College of Dentistry, Gangneung‑Wonju National University, Gangneung, Gangwon 25457, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shin</LastName>
<ForeName>Min Jea</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jo</LastName>
<ForeName>Hyo Sang</ForeName>
<Initials>HS</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Jung Hwan</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cho</LastName>
<ForeName>Su Bin</ForeName>
<Initials>SB</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Chi Hern</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yeo</LastName>
<ForeName>Hyeon Ji</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yeo</LastName>
<ForeName>Eun Ji</ForeName>
<Initials>EJ</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Choi</LastName>
<ForeName>Yeon Joo</ForeName>
<Initials>YJ</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kim</LastName>
<ForeName>Duk-Soo</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Department of Anatomy, College of Medicine, Soonchunhyang University, Cheonan‑Si, South Chungcheong 31538, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cho</LastName>
<ForeName>Sung-Woo</ForeName>
<Initials>SW</Initials>
<AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul 05505, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cho</LastName>
<ForeName>Yong-Jun</ForeName>
<Initials>YJ</Initials>
<AffiliationInfo><Affiliation>Department of Neurosurgery, Hallym University Medical Center, Chuncheon, Gangwon 24253, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sohn</LastName>
<ForeName>Eun Jeong</ForeName>
<Initials>EJ</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Son</LastName>
<ForeName>Ora</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Keun Wook</ForeName>
<Initials>KW</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Kyu Hyung</ForeName>
<Initials>KH</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Jinseu</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eum</LastName>
<ForeName>Won Sik</ForeName>
<Initials>WS</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Choi</LastName>
<ForeName>Soo Young</ForeName>
<Initials>SY</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chuncheon, Gangwon 24252, Republic of South Korea.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>06</Month>
<Day>15</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Greece</Country>
<MedlineTA>Mol Med Rep</MedlineTA>
<NlmUniqueID>101475259</NlmUniqueID>
<ISSNLinking>1791-2997</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C516006">Glrx protein, mouse</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C503924">Pep-1 peptide</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010455">Peptides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>5UX2SD1KE2</RegistryNumber>
<NameOfSubstance UI="D003543">Cysteamine</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002545" MajorTopicYN="N">Brain Ischemia</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003543" MajorTopicYN="N">Cysteamine</DescriptorName>
<QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006624" MajorTopicYN="N">Hippocampus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020935" MajorTopicYN="N">MAP Kinase Signaling System</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>06</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>01</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>6</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>10</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>6</Month>
<Day>20</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29916538</ArticleId>
<ArticleId IdType="doi">10.3892/mmr.2018.9176</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list></list>
<tree><noCountry><name sortKey="Cho, Su Bin" sort="Cho, Su Bin" uniqKey="Cho S" first="Su Bin" last="Cho">Su Bin Cho</name>
<name sortKey="Cho, Sung Woo" sort="Cho, Sung Woo" uniqKey="Cho S" first="Sung-Woo" last="Cho">Sung-Woo Cho</name>
<name sortKey="Cho, Yong Jun" sort="Cho, Yong Jun" uniqKey="Cho Y" first="Yong-Jun" last="Cho">Yong-Jun Cho</name>
<name sortKey="Choi, Soo Young" sort="Choi, Soo Young" uniqKey="Choi S" first="Soo Young" last="Choi">Soo Young Choi</name>
<name sortKey="Choi, Yeon Joo" sort="Choi, Yeon Joo" uniqKey="Choi Y" first="Yeon Joo" last="Choi">Yeon Joo Choi</name>
<name sortKey="Eum, Won Sik" sort="Eum, Won Sik" uniqKey="Eum W" first="Won Sik" last="Eum">Won Sik Eum</name>
<name sortKey="Han, Kyu Hyung" sort="Han, Kyu Hyung" uniqKey="Han K" first="Kyu Hyung" last="Han">Kyu Hyung Han</name>
<name sortKey="Jo, Hyo Sang" sort="Jo, Hyo Sang" uniqKey="Jo H" first="Hyo Sang" last="Jo">Hyo Sang Jo</name>
<name sortKey="Kim, Dae Won" sort="Kim, Dae Won" uniqKey="Kim D" first="Dae Won" last="Kim">Dae Won Kim</name>
<name sortKey="Kim, Duk Soo" sort="Kim, Duk Soo" uniqKey="Kim D" first="Duk-Soo" last="Kim">Duk-Soo Kim</name>
<name sortKey="Lee, Chi Hern" sort="Lee, Chi Hern" uniqKey="Lee C" first="Chi Hern" last="Lee">Chi Hern Lee</name>
<name sortKey="Lee, Keun Wook" sort="Lee, Keun Wook" uniqKey="Lee K" first="Keun Wook" last="Lee">Keun Wook Lee</name>
<name sortKey="Park, Jinseu" sort="Park, Jinseu" uniqKey="Park J" first="Jinseu" last="Park">Jinseu Park</name>
<name sortKey="Park, Jung Hwan" sort="Park, Jung Hwan" uniqKey="Park J" first="Jung Hwan" last="Park">Jung Hwan Park</name>
<name sortKey="Ryu, Eun Ji" sort="Ryu, Eun Ji" uniqKey="Ryu E" first="Eun Ji" last="Ryu">Eun Ji Ryu</name>
<name sortKey="Shin, Min Jea" sort="Shin, Min Jea" uniqKey="Shin M" first="Min Jea" last="Shin">Min Jea Shin</name>
<name sortKey="Sohn, Eun Jeong" sort="Sohn, Eun Jeong" uniqKey="Sohn E" first="Eun Jeong" last="Sohn">Eun Jeong Sohn</name>
<name sortKey="Son, Ora" sort="Son, Ora" uniqKey="Son O" first="Ora" last="Son">Ora Son</name>
<name sortKey="Yeo, Eun Ji" sort="Yeo, Eun Ji" uniqKey="Yeo E" first="Eun Ji" last="Yeo">Eun Ji Yeo</name>
<name sortKey="Yeo, Hyeon Ji" sort="Yeo, Hyeon Ji" uniqKey="Yeo H" first="Hyeon Ji" last="Yeo">Hyeon Ji Yeo</name>
</noCountry>
</tree>
</affiliations>
</record>

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	Serveur d'exploration sur la glutarédoxine
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Serveur d'exploration sur la glutarédoxine

PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways.

PEP‑1‑glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptotic signaling pathways.

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